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Such abnormalities may be the result of head trauma, stroke or tumours, but in most cases, the cause is unknown. However, it seems that abnormalities in partial epilepsy are different to those in generalized epilepsy. The choice of drug depends on the type of epilepsy. Combination therapy with two or more drugs may be necessary. In this case, careful monitoring is needed because unpredictable interactions between antiepileptic drugs are possible. Withdrawal from antiepileptic drugs should be gradual to avoid the risk of precipitating rebound seizures.