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Side-effect profile of modafinil is generally benign e. Rare serious dermatological reactions may occur in people with genetic predispositions and more commonly in pediatric patients, and, discontinuation is recommended at the earliest signs of rash or similar reactions. Modafinil was approved for medical use in the United States in Modafinil is not considered as a classical psychostimulant, but rather as an eugeroic used primarily for treatment of narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. For obstructive sleep apnea, it is recommended that continuous positive airway pressure CPAP be appropriately used before considering starting modafinil to help with daytime sleepiness. Since then, armed forces of several countries including the United States, the United Kingdom, India and France, have expressed interest in modafinil as an alternative to amphetamine —the drug traditionally employed in combat situations or lengthy missions where troops face sleep deprivation.

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Common side effects include daytime sleepiness, headache, nausea, and diarrhea. Zolpidem is a nonbenzodiazepine Z drug which acts as a sedative and hypnotic. Zolpidem was approved for medical use in the United States in Zolpidem is labelled for short-term usually about two to six weeks treatment of insomnia at the lowest possible dose. It can be taken if there are at least 4 hours between the time of administration and when the person must be awake.

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