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If the enzyme is inhibited these substances cause rapid elevation in blood pressure leading to a hypertensive crisis, which can be fatal. Newer selective drugs inhibit MAO-A reversibly, allowing displacement by exogenous amines and so are less likely to interact with drugs and food substances and are safer. An example is moclobemide. Nevertheless, MAOIs should be regarded as second line drugs and are indicated when the patient is resistant to other therapy, or is phobic, hysterical or has other atypical symptoms.
All patients taking MAOIs should carry a warning card highlighting the potential dangers of interaction with other drugs and food substances. Lithium is used for the prophylactic control of mania and hypomania and bipolar depression.
This is a collection of symptoms caused by the death of many cells in the tumour. A significant symptom is the production of large amounts of uric acid as a result of the breakdown of nucleic acids. High plasma levels of uric acid can precipitate gout, or interfere with treatment for pre-existing gout, or uric acid can deposit in the kidneys and cause kidney damage.
Concurrent use of allopurinol can reduce the production of uric acid. Tumour cells can become resistant to chemotherapy.
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Although lack of vitamin K is rare, because it is present in green leafy vegetables and synthesized by intestinal bacteria, it may occur with a combination of poor diet and long-term use of antibiotics. Deficiency may also occur because of malabsorption secondary to other conditions such as coeliac disease, or due to lack of bile secretion as in obstructive jaundice.
Deficiency is treated with oral vitamin K or synthetic analogues such as phytomenadione. In the absence of bile, vitamin K replacement has to be given by intramuscular or intravenous injection. Vitamin K can be used to counteract the effects of warfarin in the event of excessive bleeding.
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Because of this, it is used alone for short procedures, for example podiatric surgery. A disadvantage of propofol is that it is painful on injection.
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The only exception to this rule is when a patient must always receive the same brand of a drug because different preparations can result in different blood levels of the drug.
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Blocking of dopamine D responsible for the efficacy in therapy of schizophrenia.
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Newer ones, for example acrivastine, are preferred because they penetrate the blood-brain barrier less easily and cause less sedation.
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Bupivacaine has two to four times the potency of lidocaine and shows similar toxic effects with high doses.
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It appears to work on sodium ion channels to cause inhibition of the release of excitatory amino acids.
Other adverse effects are nausea, leukopenia, blurred vision, rashes and hair loss. Cytokines are chemicals released by damaged cells and cells involved in inflammation and repair.
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The descriptions that follow are not intended to give a comprehensive account of all anti-cancer drugs available, rather to explain the modes of action and to give examples from each group. Toxic effects with all cytotoxic drugs are severe nausea and vomiting, hair loss and bone marrow depression.
There is an antidote to paracetamol overdose (acetylcysteine) and provided it is given within eight hours a complete recovery can be made. In the liver, acetylcysteine is converted to glutathione, which forms a phentermine 37.5 mg tablet cost conjugate with paracetamol. Centrally acting analgesics are also known as narcotics or opioids. Strictly speaking, narcotic refers to the ability of a drug to induce sleep, which drugs in this group do in high dosage, but the term can be misleading and is best avoided.
Opioids are drugs that have morphine-like actions and the name comes from the source of morphine and opium, the opium poppy, Papaver somniferum. Opium itself is a mixture of substances that occur in the sap of the opium poppy.
There are three processes to the production of urine. Drugs, like waste products from online pharmacy adipex metabolism, can be subjected to all of them. The glomerulus is adapted for the filtration of water and substances dissolved in it from plasma. Pressure in the capillaries of the glomerulus forces fluid and dissolved substances into the Bowmans capsule. Most drugs are small enough to be filtered, although if they are lipid soluble they are readily reabsorbed from other parts of the kidney tubule.
Proteins are generally too large to be filtered at the glomerulus and do not appear in the urine.