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Epilepsy is caused by abnormal high-frequency firing of neurons, either in the whole of the cerebral cortex or in discrete areas of the cerebral cortex (partial epilepsy). The abnormal activity may be due to increased excitatory neuronal transmission, possibly involving abnormal sodium ion channels or decreased inhibitory transmission, possibly due to abnormality at GABA receptors.

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Authored by Kyle P. Kokko, MD, PHD

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