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Osmolality is a measure of the effect a substance can have on the movement of water and depends on the number of molecules per kilogram of water. It is measured in milliosmoles per kilogram of water. Cells and body fluids are normally in osmotic equilibrium and have an osmolality of about Addition of ions to them in the form of ionic contrast agents can alter osmolality (the adverse effects, particularly the loss of water from cells, especially blood cells.
Other adverse effects are pain on injection, endothelial damage, thrombosis, thrombophlebitis, disturbance of the bloodbrain barrier, bradycardia and increased pulmonary blood pressure. Ionic monomeric contrast agents are known as high osmolar contrast agents and are not much used nowadays because of the risk of adverse effects.
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