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Calibration curves of each compound were generated by Thermofisher Scientific Dionex Chromeleon 7. The coefficient of determination for amoxicillin was Majority of the brands of antibiotics analyzed in this study were labeled as having been produced as generics in China, Ghana, India, Ireland, and Nigeria. All 15 samples of co-trimoxazole produced a brown solution hence passing the colorimetric test, and two samples, one from Ghana and one from Nigeria, failed the TLC test Table 2.
Of the 15 co-trimoxazole purchased, 6 out of 15 However, there has since been a disengagement of most pharmaceutical companies from antibiotic research as a result of economic and regulatory challenges. The number of multinational pharmaceutical companies actively engaged in antibiotic research has fallen from 18 in to just 4 in —AstraZeneca, Novartis, GlaxoSmithKline GSK, and Sanofi-Aventis, 24 with countless numbers of generic antibiotics being manufactured globally.
Furthermore, two samples of co-trimoxazole bought and stated to be manufactured in Ghana and Nigeria, respectively, also failed the TLC test. Co-trimoxazole is the recommended drug by the WHO for use as a prophylactic therapy to decrease the burden of bacterial infections for people living with HIV and tuberculosis. These subtherapeutic tablets were all bought in Ghana and Nigeria, stating that they were manufactured in those countries, except for one that states it was manufactured in India.
All the samples passed the colorimetric test and only two failed the TLC test. However, at the population level substandard co-trimoxazole may engender drug resistance. Lack of funds and time entailed that samples were purchased using the convenience method with an overt approach. Convenience sampling is not the method of choice to determine the prevalence of poor quality drugs in a geographical region, and overt sampling may lead to responder bias as the seller is aware of the nature of the study and will provide samples that are more likely to be of good quality.
In conclusion, there has been much attention focused on the quality of antimalarials as well as the quality of antiretroviral drugs for HIV and drugs for the treatment of tuberculosis in parts of southeast Asia and sub-Saharan Africa. However, a concerted effort is needed to also determine the quality of varying brands of antibiotics in various countries. The sheer volume of antibiotics sold daily and their relatively low production cost makes them a vulnerable group of drugs for targeting by counterfeiters, illegitimate internet pharmacies, and those drug manufacturers who use poor manufacturing practices.
Investment must include improving technical capacity so that drug quality analysis can be conducted using reliable and accurate methods such as HPLC and dissolution testing to be a part of an integrated drug quality surveillance system. Baptiste Leurent is thanked for his help with the statistical analysis. Received Aug 27; Accepted Feb 1. This article has been cited by other articles in PMC. Abstract Little is known about the quality of antibiotics despite being in high demand globally.
Materials and Methods Sampling the antibiotics. Open in a separate window. Sensitivity and specificity calculations. Antibiotic treatment failure in four common infections in UK primary care — longitudinal analysis.
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