Decades of research have demonstrated an association between high levels of low-density lipoprotein cholesterol LDL-C and an increased risk of atherosclerotic cardiovascular disease ASCVD, including coronary heart disease, stroke, and peripheral arterial disease. Rosuvastatin Crestor, 20 40 mg. Pravastatin Pravachol, 40 80 mg. All of these RCTs demonstrated a reduction in major cardiovascular events. Statins and dosages listed in italics are approved by the U. There might be a biologic basis for a less-than-average response. Food and Drug Administration because of the increased risk of myopathy, including rhabdomyolysis.
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Lipid-lowering statin therapy reduces the proportional risk as effectively in older patients as in younger individuals; however, limited data are available for elderly patients with type 2 diabetes. We conducted a post hoc analysis to compare the efficacy and safety of atorvastatin among 1, patients aged 65—75 years at randomization with 1, younger patients in the Collaborative Atorvastatin Diabetes Study CARDS. The primary end point was time to first occurrence of acute coronary heart disease events, coronary revascularizations, or stroke. Corresponding absolute risk reductions were 3. The overall safety profile of atorvastatin was similar between age-groups.
Ezetimibe is a non-statin lipid-lowering medication that inhibits absorption of dietary cholesterol by blocking the Niemann-Pick C1-Like 1 protein NPC1L1. Moreover, based on a recent unique analysis of the IMPROVE-IT trial, ezetimibe reduced additional and total cardiovascular events over the course of the study, not only the first occurring event as trials are traditionally designed to assess. The expert panel stated that non-statin therapies were an important consideration in high-risk patients when a less-than-anticipated LDL-C lowering was observed. How low can we go with LDL-C? The analysis addresses the fact that patients with a nonfatal, first cardiovascular event are at risk of developing additional events.
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Rhabdomyolysis, a clinical syndrome in which skeletal muscle damage and necrosis, is precipitated by multi-therapy is most frequently described during statin treatment. Rhabdomyolysis is a rare, but serious side-effect that may lead to renal failure and dangerous electrolyte abnormalities in patients. HMG-CoA reductase inhibitors statins might cause high elevations of creatine phosphokinase CK in patients with unnoticed hypothyroidism. Statin-associated myopathy. The broad spectrum of statin myopathy: From myalgia to rhabdomyolysis. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs.
You also get it from food. Your body needs it, but too much cholesterol in your blood can clog your arteries. This increases your risk of heart disease, heart attack, and death. Statins are drugs that lower your cholesterol. Many older adults have high cholesterol. Their doctors usually prescribe statins to prevent heart disease.
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Both drugs work in the same way, helping to block a chemical necessary for making cholesterol. In turn, they help lower cholesterol, reduce risk for cardiac events and slow the progression of heart disease. Over 1, patients with heart disease participated in this study — half of whom took the maximum daily dose of atorvastatin 80 mg while the other half were prescribed the maximum daily dose of rosuvastatin 40 mg. Based on findings, atorvastatin and rosuvastatin are equally as safe and effective in lowering cholesterol and possibly reversing plaque build-up with aggressive treatment. Patients and doctors should always discuss the possible side effects of taking cholesterol-lowering drugs. Questions for You to Consider Who should take statins?
Efficacy of atorvastatin when not lipitor 75 mg daily. After a week diet period, atorvastatin was initiated at a dose of 10 mg per day. The percentage variation in costs was the parameter to evaluate the saving. Forty one patients remained throughout the study and had their weekly dosage reduced. In 25 patients the medication was administered three times a week, and in 16, five times a week, with reductions of