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Osteoarthritis is primarily a degenerative joint disease, but as joint destruction occurs this creates local inflammation. Treatment of osteoarthritis is with NSAIDs.
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Although lack of vitamin K is rare, because it is present in green leafy vegetables and synthesized by intestinal bacteria, it may occur with a combination of poor diet and long-term use of antibiotics.
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In this case, careful monitoring is needed because unpredictable interactions between antiepileptic drugs are possible.
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A drug metabolite may have a new and completely different pharmacological activity, or it may be as active as or more active than the original drug.
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The first three of the following drugs are available in many preparations as over-thecounter medicines.
Radiography, Hogg, P. and Hogg, D.
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The antiemetic effect is due to the blocking of dopamine receptors in the chemotrigger zone of the medulla. The chemotrigger zone is sensitive to potentially harmful chemicals in blood.
Griseofulvin interacts with microtubules in fungal cells preventing the formation of the spindle during mitosis. It can be used topically and orally to treat skin and nail infections. Given orally the drug is sequestered into hair and nails. Recently the topical preparation has been added to the list of drugs that qualified, registered podiatrists can access and supply. Adverse effects of griseofulvin are gastrointestinal upset, headache and photosensitivity.
Some tolerate a particular drug while others do not. In the treatment of chronic pain, a number of drugs may be tried until one is found that produces the most acceptable result to the patient. Aspirin, is often the first choice of analgesia for mild to moderate pain in adults. In large doses, aspirin has anti-inflammatory effects and has a role in the treatment of chronic inflammatory disease.
Aspirin also reduces the adhesive and aggregative properties of platelets thereby decreasing the tendency of thrombi formation.