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Next: Dosage for Bipolar Mania. Next: Major Depressive Disorder. Advise families and caregivers of the need for close observation and communication with the prescriber. Additional signs may include elevated creatine phosphokinase, myoglobinuria rhabdomyolysis, and acute renal failure. Management should include immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy, intensive symptomatic treatment, and medical monitoring, and treatment of any concomitant serious medical problems.
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