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The increase of Ga scintigraphy uptake can be seen at the amiodarone induced pulmonary toxicity. Bronchoalveolar lavage may reveal inclusion body in alveolar macrophages and type II pneumocytes of accumulated phospholipids, which are found in all patients exposed to amiodarone. This fact is not indicative of pulmonary toxicity. Primary treatment is the discontinuation of amiodarone.
Due to a long half-life approximately 45 days, pulmonary toxicity may initially progress despite not taking the drug. Systemic corticosteroids are recommended in a daily dose of 40 to 60 mg with gradually decreased dose for at least 12 months to decrease the symptoms. The prognosis is usually good. After cardiology consultation, due to the late history of acute coronary sendrom, the glucocorticoid therapy was planned for a short time and applied during his hospital stay.
We avoid long term steroid therapy because of significant clinical improvement in a short period of 72 hours. About two months later, in the outpatient examination, chest X-ray was evaluated normal. Amiodarone is the main drug known to cause pulmonary toxicity. We presented a case of acute amiodarone pulmonary toxicity that caused respiratory failure. The drug-induced lung diseases. Drug-induced pulmonary disease. Pharmacotherapy: a pathophysiologic approach.
Radiation and drug induced pneumopathies. Acute pulmonary toxicity after low-dose amiodarone therapy. Mechanisms inthe pathogenesis of amiodarone-induced pulmonary toxicity. New York: Lippincott Williams and Wilkins; Drug-induced infiltrative lung disease. Drug-induced pulmonary diseases. Interstitial lung disease. Amiodarone pulmonary toxicity.
Amiodarone-associated hemoptysis. Recognition and pathogenesis Part 1. Recognition and pathogenesis Part 2. Amiodarone toxicity presenting as a pulmonary mass and peripheral neuropathy: the continuing diagnostic challenge. Technetiumm-DTPA aerosol scintigraphy in amiodarone induced pulmonary toxicity in comparison with Ga scintigraphy. Use of iodine metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: A comparative study with technetiumm diethyltriaminepenta acetic acid radioaerosol scintigraphy.
Amiodarone associated pulmonary toxicity. There are also several other medicines that can affect the way Amiodarone works in your body.
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A year-old member patient was cordarone online to our hospital with severe pneumonia. Because bacterial infections of the bronchoalveolar lavage fluid were made and after using amiodarone for almost one contraction, we eliminated amiodarone from his medication regimen due to general of amiodarone chloroform. Accordingly, we also inherited systemic steroid therapy. At the force time, more than medications are used to cause pulmonary toxicity.
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