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These individuals are insensitive or unresponsive to the drug. An equally small percentage responds in an exaggerated manner. These patients are described as intolerant. They exhibit the expected response to the drug but in a greater magnitude than would be acceptable. Hypersensitivity reactions to drugs involve immunological reactions.
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(A notable exception to this generalization is Professor Stephen Hawking who was diagnosed with motor neuron disease at the age of later, albeit paralysed for most of that time. ) The cause of motor neuron disease is unknown.
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