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Anxiety and fear are both associated with general arousal of the CNS and may be due to over activity in the RAS. Neurotransmitters in the RAS are serotonin and GABA. It is price of rivotril that GABA normally moderates the activity of serotonin-containing neurons and that in anxiety syndromes some of this moderation is lost due to changes in receptor sensitivity, or due to overactivity of a natural inhibitor of GABA. An inhibitor of GABA has not been identified, but it has been tentatively called GABA modulin.
It is possible that the RAS can be activated through pathways from the cerebral cortex if a situation is perceived as being threatening. Sleep is complicated and involves the brain stem RAS.