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Plasma protein binding therefore reduces active drug concentration and ultimate response to the drug. Drugs can compete for the same protein binding sites and this is a form of drug interaction. A well-known and important example is that of warfarin and aspirin. Warfarin is an anticoagulant, which binds extensively to plasma proteins, and this is taken into account when dosages are worked out.

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Authored by Dr. Garrett Alan Hauptman, MD

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