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The mechanism of action of bisphosphonates is not completely understood. They are deposited in place of normal bone and may slow bone turnover because they are resistant to degradation by enzymes produced by osteoclasts or they may inhibit the activity of osteoclasts.
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The management of serious adverse reactions to contrast agents antihistamine, hydrocortisone and salbutamol. Radiographers who inject contrast agents must be trained in emergency treatment and basic life support.
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In the United Kingdom, podiatrists have had access to a range of POMs by means of an exemption order (since administered local anaesthetics) for administration, sale or supply (and recently, November a number of antibiotics and some NSAIDs.
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